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Review Article Invasiveness of Pseudomonas aeruginosa and Its Role in Diversity of Pseudomonal Infectious Diseases


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Title: Review Article Invasiveness of Pseudomonas aeruginosa and Its Role in Diversity of Pseudomonal Infectious Diseases
Authors: Hirakata, Yoichi
Issue Date: 17-Dec-2002
Citation: Acta medica Nagasakiensia. 2002, 47(3-4), p.89-96
Abstract: Pseudomonas aeruginosa causes both invasive (bacteremic) and chronic non-invasive infections in several organs, resulting in the diversity of infectious diseases. When Madin- Darby canine kidney (MDCK) monolayers were infected with clinical isolates of P. aeruginosa, significantly (P < 0.001) more blood (30 of 32, 93.7%) than respiratory (25 of 45, 54.4%) isolates penetrated the epithelial cell monolayers by 3 h. Only eight (4 blood and 4 respiratory) isolates were cytotoxic and possessed exo U, and passed through the monolayer following epithelial cell death associated with release of lactose dehydrogenase and a marked drop in transepithelial electrical resistance. Thus, invasiveness was usually independent of cytotoxicity. The capacity to penetrate epithelial cells appears to be a critical determinant of invasiveness in susceptible hosts and may be controlled by unknown unique genes. In addition, such invasion determinant(s) are thought to be predominantly exported by P. aeruginosa via MexAB-OprM, which is one of multi-drug resistant (MDR) efflux systems. Hence, MDR efflux systems in P. aeruginosa might be critical for the efflux of virulence factors, in addition to their established role of exporting harmful substances such as antibiotics or detergents.
Keywords: Pseudomonas aeruginosa / invasiveness / cytotoxicity / multi-drug resistant efflux system
URI: http://hdl.handle.net/10069/16217
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 47, No. 3-4

Citable URI : http://hdl.handle.net/10069/16217

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