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Severity of Glomerulosclerosis Predicts Prognosis of IgA Nephropathy with Proteinuria


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Title: Severity of Glomerulosclerosis Predicts Prognosis of IgA Nephropathy with Proteinuria
Authors: Horita, Yoshio / Tadokoro, Masato / Suyama, Naofumi / Taura, Kouichi
Issue Date: 17-Dec-2002
Citation: Acta medica Nagasakiensia. 2002, 47(3-4), p.123-126
Abstract: We determined the natural history of IgA nephropathy (IgAN) among patients who presented with proteinuria, and factors associated with the development of clinical events, namely blood pressure(BP)竕ァ130/85 mmHg, serum creatinine 竕ァ1.4mg/dl. We analyzed data from 16 patients(mean age 35 ツア 14 years) with IgAN accompanied by proteinuria between 1990 and 1998. We also semiquantified scores of glomerulosclerosis (GS), tubulointerstitial damage (TID), hyaline arteriosclerosis (HA), and IgAN classification. The median duration of follow-up was 48 months. During clinical follow-up, seven (44%) patients became hypertensive, among who five (31%) developed impaired renal function and two (13%) progressed to treatment with hemodialysis. Events did not develop in the other 9 patients (56%). Clinical findings were not significantly different between the events and event-free groups. The GS and TID scores revealed significant differences between patient groups. Only the renal histological parameters of GS and events were statistically correlated with renal survival. We conclude that the severity of GS may be the important prognostic factor inpatients with IgAN accompanied by proteinuria at the time of the initial biopsy.
Keywords: IgA nephropathy / proteinuria / glomerulosclerosis / hypertension
URI: http://hdl.handle.net/10069/16222
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 47, No. 3-4

Citable URI : http://hdl.handle.net/10069/16222

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