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Two Cases of Multiple Carcinoid Tumors and Gastric Enterochromaffin-like Cell Hyperplasia, Dysplasia and Neoplasia in Type A Gastritis


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Title: Two Cases of Multiple Carcinoid Tumors and Gastric Enterochromaffin-like Cell Hyperplasia, Dysplasia and Neoplasia in Type A Gastritis
Authors: Alipov, Gabit / Nakashima, Masahiro / Nakayama, Toshiyuki / Fukuda, Eiichiro / Niino, Daisuke / Fukuda, Hirotoshi / Yamada, Masafumi / Kishikawa, Hiroki / Sekine, Ichiro
Issue Date: 17-Dec-2002
Citation: Acta medica Nagasakiensia. 2002, 47(3-4), p.171-175
Abstract: We describe two cases of multiple carcinoids and hyperplasia, dysplasia and neoplasia of enterochromaffin-like (ECL) cells associated with atrophic gastritis type A in the stomach. Multiple polypoid lesions measuring 1 cm showed upper gastroendoscopic features. They were all found in the upper body of the stomach. All polypoid lesions with carcinoid foci were observed from the deeper layers of the propria mucosa to the submucosa and were surrounded by ECL cells. In one case, the serum gastrin level which was as high as 1700 pg/mi, returned to normal range (17 pg/ml) after gastrectomy. It is suggested that longstanding hypergastrinemia may have played a causative role in the development of multiple gastric carcinoid tumors. A total gastrectomy was considered essential for treatment of aggressive multiple carcinoid tumors with hypergastrinemia.
Keywords: gastric carcinoid / enterochromaffin-like (ECL) cells / type A gastritis
URI: http://hdl.handle.net/10069/16231
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 47, No. 3-4

Citable URI : http://hdl.handle.net/10069/16231

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