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Differential Effects of the Sedative Agents on the Heart Rate Response to Intravenous Isoproterenol Infusion.


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Title: Differential Effects of the Sedative Agents on the Heart Rate Response to Intravenous Isoproterenol Infusion.
Authors: Guo, Huan / Takahashi, Shunji / Cho, Sungsam
Issue Date: 24-Dec-2003
Citation: Acta medica Nagasakiensia. 2003, 48(3-4), p.149-152
Abstract: Bradycardia is one of the adverse events associated with the sedatives, dexmedetomidine (DM) and propofol (PF). Because PF and DM attenuate the heart rate (HR) response to intravenous (IV) atropine, isoproterenol may be required for the treatment of bradycardia during DM or PF sedation. Therefore, we conducted the current study to evaluate the effect of DM or PF on the response of HR to IV isoproterenol. Male Sprague-Dawley rats were randomly allocated to one of three groups. Group C (n=7) received sodium pentobarbital intraperitonealy and IV saline. Group PF (n=7) received IV PF. Group DM (n=7) received IV DM. Then all groups received IV isoproterenol at incremental infusion rates (0.1, 0.3, 0.5, 1.0, and 3.0 ng/kg/min for 2 min each dose). Blood pressure decreased significantly in the groups C and DM, and HR decreased significantly in group DM after administration of each sedative. The increases in HR at 0.5, 1.0, and 3.0 ng/kg/min isoproterenol in group DM were 7 5ツア41, 86ツア36, and 110ツア39 beats/min, respectively, and were greater as compared with those in group C (35ツア29, 38ツア30, and 57ツア32 beats/min, respectively), but there were no significant differences between groups C and PF. In conclusion, DM but not PF enhances the HR response to the continuous IV infusion of isoproterenol, suggesting that isoproterenol may be useful when atropine is ineffective for the treatment of bradycardia during DM or PF sedation. (245 words)
Keywords: dexmedetomidine / propofol / isoproterenol / heart rate
URI: http://hdl.handle.net/10069/16259
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 48, No. 3-4

Citable URI : http://hdl.handle.net/10069/16259

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