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Respiratory Bronchiolitis-associated Interstitial Lung Disease with Unusual Histopathological Findings

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Title: Respiratory Bronchiolitis-associated Interstitial Lung Disease with Unusual Histopathological Findings
Authors: Tomari, Shinya / Matsuse, Hiroto / Mukae, Hiroshi / Kohno, Shigeru
Issue Date: 24-Dec-2003
Citation: Acta medica Nagasakiensia. 2003, 48(3-4), p.175-177
Abstract: Respiratory bronchiolitis-associated interstitial lung disease (RB-ILD) is a mild inflammatory reaction commonly seen in asymptomatic young male cigarette smokers. This report describes unusual pathological findings in a 63-yearold Japanese female with RB-ILD. She had a 40 pack-year smoking history. Chest computed tomography showed multiple patchy shadows, especially in the right lower lobe. Diagnosis could not be established by bronchoalveolar lavage and transbronchial lung biopsy. Thoracoscopic lung biopsy was performed from right S5 and S9, which demonstrated the typical pathological findings of RB-ILD, including the presence of pigmented macrophages within respiratory bronchioles, thickening of alveolar septa by fibrosis, accumulation of intrapulmonary blue bodies and lack of granulomatous changes. Our patient had atypical RB-ILD based on old age at presentation (commonly -40 years of age), marked fibrosis and presence of numerous blue bodies.
Keywords: respiratory bronchiolitis-associated with interstitial lung disease / pigmented macrophage / fibrosis / blue body / desquamative interstitial pneumonia
URI: http://hdl.handle.net/10069/16263
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 48, No. 3-4

Citable URI : http://hdl.handle.net/10069/16263

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