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Midkine expression correlating with growth activity and tooth morphogenesis in odontogenic tumors


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Title: Midkine expression correlating with growth activity and tooth morphogenesis in odontogenic tumors
Authors: Fujita, Shuichi / Seki, Sachiko / Fujiwara, Mutsunori / Ikeda, Tohru
Issue Date: May-2008
Citation: Human Pathology, 39(5), pp.694-700; 2008
Abstract: Midkine (MK; a low molecular weight heparin-binding growth factor) is a multifunctional cytokine. MK plays a role in morphogenesis of many organs including teeth through epithelial-mesenchymal interactions. We immunohistochemically examined MK expression in various human odontogenic tumors. There was no difference in positive rate and intensity of MK between benign odontogenic tumors and their malignant counterparts. Ameloblastoma showed MK localization in the peripheral columnar cells in budding processes from the parenchyma, which frequently expressed proliferating cell nuclear antigen. MK was also preferentially expressed in keratinized cells in acanthomatous ameloblastoma and keratocystic odontogenic tumor. In odontogenic mixed tumors except for odontoma, intense immunoreactivity to MK was found in epithelial follicles, the surrounding odontogenic ectomesenchymal tissue, and the basement membrane between them. Intensity in the odontogenic ectomesenchyme decreased in relation to distance from the epithelial follicles. No expression was found in tumor cells associated with production of dental hard tissues in odontogenic mixed tumors including odontoma. These findings suggested that MK is involved in the reciprocal interaction between odontogenic epithelium and odontogenic ectomesenchymal tissue in areas without dental hard tissue formation in odontogenic mixed tumors. Coexpression of MK and proliferating cell nuclear antigen was also observed in epithelial follicles and highly cellular nodules in the ectomesenchyme of odontogenic mixed tumors. MK is considered to mediate growth activity of odontogenic tumors and cell differentiation of odontogenic mixed tumors through molecular mechanisms similar to those involved in morphogenesis of the tooth.
Keywords: Epithelial-mesenchymal interaction / Immunohistochemistry / Midkine / Odontogenic tumor / PCNA
URI: http://hdl.handle.net/10069/16316
ISSN: 00468177
DOI: 10.1016/j.humpath.2007.09.014
PubMed ID: 18329695
Rights: Copyright © 2008 Elsevier Inc. All rights reserved.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/16316

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