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Kinetic resolution of vic-amino alcohols catalyzed by a chiral Cu(II) complex


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Title: Kinetic resolution of vic-amino alcohols catalyzed by a chiral Cu(II) complex
Authors: Mitsuda, Masaru / Tanaka, Tomoaki / Demizu, Yosuke / Onomura, Osamu / Matsumura, Yoshihiro
Issue Date: 13-Nov-2006
Publisher: Elsevier
Citation: Tetrahedron Letters 47(46) pp.8073-8077, 2006
Abstract: Kinetic resolution of N-benzoylated vic-amino alcohols was achieved by benzoylation in the presence of copper triflate and (R,R)-Ph-BOX as catalysts. The observed enantioselectivity was moderate to high. The method was applied to a kinetic resolution of racemic prolinol and piperidinemethanol derivatives as well as an asymmetric desymmetrization of 2-amino-1,3-diol derivatives.
Keywords: Kinetic resolution / vic-Amino alcohol / Monobenzoylation / Chiral copper complex
URI: http://hdl.handle.net/10069/16335
ISSN: 00404039
DOI: 10.1016/j.tetlet.2006.09.049
Rights: Copyright © 2006 Elsevier Ltd All rights reserved.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/16335

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