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New organic activators for the enantioselective reduction of aromatic imines with trichlorosilane


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Title: New organic activators for the enantioselective reduction of aromatic imines with trichlorosilane
Authors: Onomura, Osamu / Kouchi, Yoshimi / Iwasaki, Fumiaki / Matsumura, Yoshihiro
Issue Date: 29-May-2006
Publisher: Elsevier
Citation: Tetrahedron Letters 47(22) pp.3751-3754, 2006
Abstract: N-Picolinoyl-(2S)-(diphenylhydroxymethyl)pyrrolidine was found to work as an organic activator in the reduction of aromatic imines to the corresponding amines by Cl3SiH. The highest selectivity was 80% ee. These are the first data showing that N-formyl group is not always essential as N-protecting group of pyrrolidine derivatives for the reduction of imines by Cl3SiH.
Keywords: Organocatalysis / Asymmetric reduction / Imines / Optically active amines
URI: http://hdl.handle.net/10069/16336
ISSN: 00404039
DOI: 10.1016/j.tetlet.2006.03.122
Rights: Copyright © 2006 Elsevier Ltd All rights reserved.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/16336

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