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Dentin phosphophoryn promotes cellular migration of human dental pulp cells


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Title: Dentin phosphophoryn promotes cellular migration of human dental pulp cells
Authors: Yasuda, Yoshiyuki / Izumikawa, Masanobu / Okamoto, Kuniaki / Tsukuba, Takayuki / Saito, Takashi
Issue Date: May-2008
Citation: Journal of Endodontics, 34(5), pp.575-578; 2008
Abstract: Dentin phosphophoryn (DPP) is a dentin sialophosphoprotein gene product that has an RGD motif and repeat sequences of aspartic acid and phosphoserine. To date, the function of DPP in the early stage of reparative dentin formation still remains unclear. The objective of this study was to evaluate the effects of DPP on pulp cell migration and proliferation. DPP promoted cell migration in a concentration-dependent manner, thus increasing it by about 3-fold at 1000 ng/mL compared with the control, but it had no effect on cell proliferation. Dephosphorylated DPP also promoted cell migration, similarly to DPP. However, cell migration was significantly suppressed by the addition of αvβ3 integrin antibody to the medium. Furthermore, porcine DPP-derived RGD peptide, but not its mutant RAD peptide, significantly promoted cell migration. These results indicated that the RGD motif of DPP plays an important role in the migration of human dental pulp cells.
Keywords: Phosphophoryn / dentin sialophosphoprotein / migration / RGD motif / dental pulp cells / reparative dentin
URI: http://hdl.handle.net/10069/16409
ISSN: 00992399
DOI: 10.1016/j.joen.2008.02.018
Rights: Copyright © 2008 American Association of Endodontists Published by Elsevier Inc.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/16409

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