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Efficacy of SPK-843, a Novel Polyene Antifungal, in Comparison with Amphotericin B, Liposomal Amphotericin B, and Micafungin against Murine Pulmonary Aspergillosis


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Title: Efficacy of SPK-843, a Novel Polyene Antifungal, in Comparison with Amphotericin B, Liposomal Amphotericin B, and Micafungin against Murine Pulmonary Aspergillosis
Authors: Kakeya, Hiroshi / Miyazaki, Yoshitsugu / Senda, Hisato / Kobayashi, Tsutomu / Seki, Masafumi / Izumikawa, Koichi / Yanagihara, Kazunori / Yamamoto, Yoshihiro / Tashiro, Takayoshi / Kohno, Shigeru
Issue Date: May-2008
Publisher: American Society for Microbiology.
Citation: Antimicrobial Agents and Chemotherapy, 52(5), p.1868-1870; 2008
Abstract: SPK-843, a new polyene antifungal, exhibited dose-dependent efficacy on murine pulmonary aspergillosis models. SPK-843 doses of higher than 1.0 mg/kg of body weight exhibited no renal toxicities and a tendency toward better survival prolongation than the estimated maximum tolerated doses of amphotericin B (Fungizone) (1.0 mg/kg) and liposomal amphotericin B (AmBisome) (8.0 mg/kg).
URI: http://hdl.handle.net/10069/16903
ISSN: 00664804
DOI: 10.1128/AAC.01369-07
PubMed ID: 18299412
Rights: Copyright (c) 2008, American Society for Microbiology. All Rights Reserved.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/16903

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