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Efficacy of SPK-843, a Novel Polyene Antifungal, in a Murine Model of Systemic Cryptococcosis


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Title: Efficacy of SPK-843, a Novel Polyene Antifungal, in a Murine Model of Systemic Cryptococcosis
Authors: Hiroshi, Kakeya / Miyazaki, Yoshitsugu / Senda, Hisato / Kobayashi, Tsutomu / Seki, Masafumi / Izumikawa, Koichi / Yamamoto, Yoshihiro / Yanagihara, Kazunori / Tashiro, Takayoshi / Kohno, Shigeru
Issue Date: May-2008
Publisher: American Society for Microbiology
Citation: Antimicrobial Agents and Chemotherapy, 52(5), p.1871-1872; 2008
Abstract: SPK-843, a new polyene antifungal, possessed efficacy in a murine model of systemic infection caused by Cryptococcus neoformans. The administration of 4.0 mg/kg SPK-843 led to better survival prolongation and fungal reduction than those observed with the administration of 0.7 mg/kg amphotericin B and 80 mg/kg fluconazole (P < 0.001), without histopathological renal changes.
URI: http://hdl.handle.net/10069/16904
ISSN: 00664804
DOI: 10.1128/AAC.01370-07
PubMed ID: 18299408
Rights: Copyright (c) 2008, American Society for Microbiology. All Rights Reserved.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/16904

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