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Radiation and Ageing An Electron Microscopic Observation and Morphometrical Study on Lipofuscin in the Cerebellar Purkinje Cells, Myocardial Cells and Hepatic Cells


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Title: Radiation and Ageing An Electron Microscopic Observation and Morphometrical Study on Lipofuscin in the Cerebellar Purkinje Cells, Myocardial Cells and Hepatic Cells
Authors: Kiyoto, Shinkai
Issue Date: Oct-1986
Citation: Acta Medica Nagasakiensia. 1986, 31(1-4), p.14-30
Abstract: Four-week old and twelve-week old female Wistar rats were used in a long-term survival experiment undertaken as an investigation of ageing in the living body. Lipofuscin in the Purkinje cells, myocardial cells and hepatic cells of the rats was observed electron microscopically, and ageing in the living body was investigated by morphometrical analysis of lipofuscin. At the same time, the acceleration of ageing due to irradiation was investigated. As a result, the accumulation of lipofuscin with ageing in Purkinje cell and myocardial cell corresponding to a post-mitotic cell was shown in both irradiated and control groups. For that reason, it was conjectured that lipofuscin can be regarded as a morphological marker, although the accumulation of lipofuscin in hepatic cells having high regeneration potential was not shown. Therefore, it is difficult to regard lipofuscin in hepatic cells as a morphological marker. Comparing the 300R irradiated group with control group, a significant difference (p<0.05, p<0.01) concerning accumulation of lipofuscin was shown in only Purkinje cells. The correlation between accumulation of lipofuscin and ageing in 300R irradiated groups showed a more significant difference (p<0.05) than that in control groups, on the basis of regression lines calculated in the three kinds of cell.
URI: http://hdl.handle.net/10069/17472
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 31, No. 1-4

Citable URI : http://hdl.handle.net/10069/17472

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