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Complement Activity in Carcinoma of the Digestive Tract


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Title: Complement Activity in Carcinoma of the Digestive Tract
Authors: Soeda, Osamu
Issue Date: Oct-1986
Citation: Acta Medica Nagasakiensia. 1986, 31(1-4), p.160-174
Abstract: The function of the complement and its affection by operative insults were evaluated in patients with carcinoma of the digestive tract in comparison with 7 benign diseases and 4 critical patients. The C4 levels in the patients undergoing major operative insult and exposed prolonging operation time were significantly reduced. There was no tendency toward a certain alteration in C3, Factor B activity, CH50 and Factor H. whereas ACH50 was reduced until the 3rd day of operation. It was suggested of delayed recovery in alternativee pathway. Moreover, the protease inhibitor (α1-Antitrypsin, α2-Macrogloburin), which acts as an inhibitor of complement activity, and the ω-amino-acid (Arg, Lys) were markedly increased when a nutritional condition in cancer patient had been improved in help of TPN. It, however, was not statiscally significant. The complex release activity of the complement was increased according to advancing disease stage in gastric cancer. In contrast, it was much depressed in hepatic cancer in relation to liver function of C3 production. In conclusion, the complement activity related to surgery in carcinoma of the digestive tract was variably influenced by the degree of an operative insult and the staging of cancer disease including the nutritional status.
URI: http://hdl.handle.net/10069/17483
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 31, No. 1-4

Citable URI : http://hdl.handle.net/10069/17483

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