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Evaluation of Cycolsporin A versus Azathioprine in Bronchial Healing of Canine Lung Allografts at Anastomosis


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Title: Evaluation of Cycolsporin A versus Azathioprine in Bronchial Healing of Canine Lung Allografts at Anastomosis
Authors: Hashimoto, Satoru
Issue Date: 25-Oct-1987
Citation: Acta Medica Nagasakiensia. 1987, 32(1-4), p.48-60
Abstract: Bronchial healing at anastomosis was compared between autografts and allografts with respect to regeneration of interrupted bronchial artery and tensile strength at the site of bronchial anastomosis following canine lung transplantation, and also compared with the effects between azathioprine and cyclosporin A. The results were as follows (1) In autografts, the bronchial healing at anastomosis was achieved after the 14th day, the regeneration of the bronchial artery was completed at 14 days, keeping satisfactory tensile strength to avoid bronchial disruption. (2) In allografts treated with azathioprine, the bronchial healing at anastomosis was delayed at 21 days or more.(3) In allografts treated with cyclosporin A, both regeneration of bronchial artery and acquisition of strong tensile strength were confirmed as good as these in autografts at 14 days or more. It was concluded that bronchial healing in lung allografts was not so impaired by cyclosporin A as observed by azathioprine.
URI: http://hdl.handle.net/10069/17509
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 32, No. 1-4

Citable URI : http://hdl.handle.net/10069/17509

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