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Flow Cytometric Analysis of the Cellular DNA Content in Various Liver Diseases


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Title: Flow Cytometric Analysis of the Cellular DNA Content in Various Liver Diseases
Authors: Omagari, Katsuhisa / Imanishi, Takeo / Makiyama, Kazuya
Issue Date: 25-Dec-1992
Citation: Acta Medica Nagasakiensia. 1992, 37(1-4), p.5-8
Abstract: Flow cytometric analysis of the cellular DNA content was conducted using paraffin-embedded liver tissues. Of the 488 cases examined, 413 (84.6%) cases were suitable for analysis. Of these, 296 (88.9%) were diploid and 37 (11.1%) were aneuploid. The ploidy pattern was unaffected by patients' sex and age. Long-term stored tissues were as suitable for analysis as short-term stored ones. An aneuploid pattern was more frequently found in hepatocellular carcinoma (HCC) (17/43,39.5%) than in non-neoplastic liver conditions (20/284,7.0%) (p<0.01). The ploidy pattern was determined to be one of the most important prognostic factors in HCC. An aneuploid pattern was also found in non-neoplastic liver conditions such as liver cirrhosis (LC) and chronic hepatitis caused by hepatitis virus (CH). It seems that the ploidy pattern and proliferative index (S+G2M fraction) do not always affect carcinogenesis in non-neoplastic liver conditions. Thus, flow cytometric analysis of the cellular DNA content using paraffin-embedded specimens is useful for determining the prognostic significance in HCC, although the significance is uncertain in non-neoplastic liver conditions.
URI: http://hdl.handle.net/10069/17547
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 37, No. 1-4

Citable URI : http://hdl.handle.net/10069/17547

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