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Kinetics of Thermotolerance Induced in Mouse FM3A Cells and Its Suppression by Drugs


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Title: Kinetics of Thermotolerance Induced in Mouse FM3A Cells and Its Suppression by Drugs
Authors: Qi, Yuling
Issue Date: 25-Dec-1992
Citation: Acta Medica Nagasakiensia. 1992, 37(1-4), p.16-24
Abstract: One of the biological problems of hyperthermia in its application to cancer treatment is thermotolerance, or transient thermoresistance in cell killing. Thermotolerance is induced by fractionated heating, by step-up heating and even during successive heating. In clinical hyperthermia thermotolerance will reduce therapeutic effectiveness. Kinetics of thermotolerance induced in mouse FM3A cells by fractionated heating and by step-up heating was analyzed in this study. Cepharanthin, as a modifier of cell membrane, and cisplatin, an anti-tumor drug, were examined if these drugs suppress the thermotolerance. It was found that these drugs suppressed thermotolerance in processes of the development and the expression of the induction of thermotolerance. As these drugs effectively suppressed the induction f hyperthermia, they can be beneficially used in combination with hyperthermia to improve therapeutic results.
URI: http://hdl.handle.net/10069/17549
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 37, No. 1-4

Citable URI : http://hdl.handle.net/10069/17549

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