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A Study of Cytocidal Effects According to the Type of Anticancer Agent Combined with OK-432

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Title: A Study of Cytocidal Effects According to the Type of Anticancer Agent Combined with OK-432
Authors: Tagawa, Yutaka / Nakazaki, Takayuki / Sawai, Terumitsu / Akama, Fumitaka / Jibiki, Masaaki / Yamaguchi, Shinya / Matsuo, Toshikazu / Tomita, Masao
Issue Date: 25-Dec-1992
Citation: Acta Medica Nagasakiensia. 1992, 37(1-4), p.110-113
Abstract: This study was performed for the evaluation of combined effects of OK-432 and anticancer agents on K562 cells in vitro. On the growth curve, an increase of cytocidl effects was not observed by co-operative action of OK-432 and Cisplatin, but such increase was found with OK-432 and VP-16. It was evident than there are the difference depending on the type of anticancer agent combined with OK-432. When this difference was investigated on the cell cycle, G2M phase accumulation was delayed with OK-432 and Cisplatin. On the other hand, this delay was not observed with OK-432 and VP-16. It was suggested that the degree of this G2M phase accumulation might affect the cytocidal effects on cancer cells.
Keywords: OK-432, Cisplatin, VP-16, Cell cycle
URI: http://hdl.handle.net/10069/17569
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 37, No. 1-4

Citable URI : http://hdl.handle.net/10069/17569

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