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A Study on the Expression of EGFR and c-erbB-2 and Nuclear DNA Content in the Stomach Cancer Tissue


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Title: A Study on the Expression of EGFR and c-erbB-2 and Nuclear DNA Content in the Stomach Cancer Tissue
Authors: Nakazaki, Takayuki
Issue Date: 25-Dec-1992
Citation: Acta Medica Nagasakiensia. 1992, 37(1-4), p.133-137
Abstract: The expression of EGFR and c-erbB-2 as well as the measurement of nuclear DNA content was evaluated in stomach cancer tissues. In addition, changes in the expression of EGFR in stomach cancer cells in mixed culture with lymphocytes were also studied by flowcytometry. The frequencies of expression of EGFR and c-erb B-2 and of the aneuploid pattern in analysis of nuclear DNA content were 35.5% and 59.3%, in the primary focus respectively. By histological types, the rates of positive c-erbB-2 expression and the appearance of aneuploidy were high in differentiated cancer, while the EGFR expression rate showed no difference according to histological types. As to lymph node metastasis, the involvement of the lymph nodes in EGFR-positive cases was more significant than that in EGFR-negative viz. 86.4% vs. 43.2%. On the other hand, the attitude of EGFR expression was clearly altered when stomach cancer cells were incubated with lymphocytes. It is possible to draw the conclusion that the weaker the expression of EGFR in stomach cancer cells, the greater the susceptibility to lymphocytes in gastric cancer cells.
URI: http://hdl.handle.net/10069/17574
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 37, No. 1-4

Citable URI : http://hdl.handle.net/10069/17574

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