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p53 protein expression in colorectal tumors in terms of PCNA and DNA ploidy analysis


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Title: p53 protein expression in colorectal tumors in terms of PCNA and DNA ploidy analysis
Authors: Ogawa, Toshiyuki
Issue Date: 25-Dec-1992
Citation: Acta Medica Nagasakiensia. 1992, 37(1-4), p.171-175
Abstract: The expression of a p53 protein was studied by using immunohistochemical technique in 44 patients with colorectal adenoma and 139 patients with colorectal cancer in comparison with the proliferating cell nuclear antigen (PCNA), one of antigens associated with cell proliferation, as well as the DNA ploidy. The positive p53 protein expression was seen in 15.9 and 61.5% of patients with colorectal adenoma and cancer, respectively. The positive rata of carcinoma was significantly higher than that of adenoma. In adenomas, the p53 expression was not associated with their histological types. However, it had become significantly increased when the degree of the atypia was moderate/severe or more advanced and in tumors as large as 10 mm or greater in diameter. These findings suggest that p53 may play an important role in the process of malignant transformation of colorectal adenoma .Furthermore, the expression of p53 protein was evaluated in comparison with clinicopathological findings, PCNA, DNA ploidy pattern in colorectal cancer. As a result, the positive p53 protein indicated a trend toward high lymphnode metastasis, a high PCNA labeling index and aneuploidy pattern of DNA analysis showed biologically malignant behavior of malignant cells, demontrating that the p53 portein was not in association with the progression of cancer.
URI: http://hdl.handle.net/10069/17583
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 37, No. 1-4

Citable URI : http://hdl.handle.net/10069/17583

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