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Assessment of Malignant Potential and Prognostic Correlation in Colorectal Carcinomas Using Monoclonal Antibody Ki-67.

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Title: Assessment of Malignant Potential and Prognostic Correlation in Colorectal Carcinomas Using Monoclonal Antibody Ki-67.
Authors: Kawazoe, Naoki
Issue Date: 14-Jan-1993
Citation: Acta Medica Nagasakiensia. 1993, 38(1), p.9-14
Abstract: The growth fraction in 103 patients with colorectal carcinoma was determined using immunohistochemical staining with the monoclonal antibody Ki-67. The results were correlated with histopathologic findings and clinical outcome. Carcinomas showed a wide range of Ki-67 labeling index (LI), reflecting variation in proliferative activity. Ki-67 LI values paralleled those of the Mitotic Index and DNA polymerase α LI, but were not consistent with the results of DNA flow cytometric analysis, Ki-67 LI was significantly lower in carcinomas confined to the mucosa and submucosa than in those invading the muscularis propria. Poorly differentiated carcinomas demonstrated significantly high LI compared with those that were moderate of well differentiated. Ki-67 LI was particularly higher in carcinomas with Iymphatic invasion and/or venous invasion than those without invasion. No correlation of Ki-67 LI with lymph node metastasis or liver metastasis could be found. Four recurrent cases had significantiy high LI as compared with gighty-six cases with primary colorectal carcinoma. Carcinomas with high Ki-67 LI (greater than 30%) implicated in poor prognosis, whereas those with low Ki-67 LI demonstrated favorable prognosis. Immunohistochemical staining of proliferating cells using the Ki-67 monoclonal antibody in not only colorectal carcinomas but also other carcinomas is useful for assessing malignant potential and prognosis.
URI: http://hdl.handle.net/10069/17596
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 38, No. 1

Citable URI : http://hdl.handle.net/10069/17596

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