DSpace university logo mark
Advanced Search
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > University Hospital > Articles in academic journal >

Ocular Pharmacokinetic/Pharmacodynamic Modeling for Timolol in Rabbits Using a Telemetry System


File Description SizeFormat
BPB31_970.pdf195.1 kBAdobe PDFView/Open

Title: Ocular Pharmacokinetic/Pharmacodynamic Modeling for Timolol in Rabbits Using a Telemetry System
Authors: Sakanaka, Koji / Kawazu, Kouichi / Tomonari, Masahide / Kitahara, Takashi / Nakashima, Mikiro / Nishida, Koyo / Nakamura, Junzo / Sasaki, Hitoshi / Higuchi, Shun
Issue Date: 1-May-2008
Publisher: The Pharmaceutical Society of Japan
Citation: Biological & Pharmaceutical Bulletin, 31(5), pp.970-975; 2008
Abstract: We have established an ocular pharmacokinetic/pharmacodynamic (PK/PD) model for a β-adrenergic antagonist, timolol, after instillation into rabbits. Timolol concentrations were determined by HPLC in the tear fluid, aqueous humor, cornea, and iris-ciliary body after instillation or ocular injection into the anterior chamber of the eye in rabbits. In addition, intraocular pressure (IOP) measurement was performed after instillation of timolol by a telemetry system, which was able to obtain detailed IOP data automatically. The PK/PD parameters were estimated by fitting the concentration--time profiles and the ocular hypotensive effect--time profiles using MULTI (RUNGE) program. The PK model consisted of six compartments and the PD model included aqueous humor dynamics based on an action mechanism of timolol, which causes lowering of IOP by suppressing aqueous humor production. The PK/PD model described well the concentration--time profiles and the ocular hypotensive effect--time profiles after instillation of timolol. This study is the first trial to develop an ocular PK/PD model for timolol after instillation. This model can predict both the drug concentrations in various ocular tissues and the ocular hypotensive effect after instillation of timolol.
Keywords: pharmacokinetic / pharmacodynamic / eye / timolol / telemetry system
URI: http://hdl.handle.net/10069/17913
ISSN: 09186158
DOI: 10.1248/bpb.31.970
Rights: (c) 2008 The Pharmaceutical Society of Japan
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/17913

All items in NAOSITE are protected by copyright, with all rights reserved.

 

Valid XHTML 1.0! Copyright © 2006-2015 Nagasaki University Library - Feedback Powerd by DSpace