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Primary Structure of Hb 3, a Major Hemoglobin, of Bonnet Monkey (Macaca Radiata)


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Title: Primary Structure of Hb 3, a Major Hemoglobin, of Bonnet Monkey (Macaca Radiata)
Other Titles: ボンネットモンキー(Macaca radiata)の主要ヘモグロビンHb3の一次構造
Authors: Watanabe, Bunji / Maita, Tetsuo / Matsuda, Genji
Authors (alternative): 渡辺, 文治 / 毎田, 徹夫 / 松田, 源治
Issue Date: 31-Mar-1988
Citation: 長崎大学医療技術短期大学部紀要 = Bulletin of the School of Allied Medical Sciences, Nagasaki University. 1988, 1, p.43-56
Abstract: 分子進化を知る目的で,多くのヘモグロビンの一次構造が報告されている.今回著者らは旧世界猿のマカク属に分類されるボンネットモンキーの主要ヘモグロビンHb1~Hb3の中,Hb3のα鎖およびβ鎖の一次構造を決定し,ヒトならびに同属のヘモグロビンと比較した.ヒトとの比較ではα鎖で3箇所68Leu←→Asn,71Gly←→Ala,78His←→Asn,β鎖で7箇所9Asn←→Ser,13Thr←→Ala,50Ser←→Thr,76Asn←→Ala,87Gln←→Thr,104Lys←→Arg,125Gln←→Proのアミノ酸置換が認められた.また同属の他のヘモグロビンとの比較検討も行った.さらにボンネットモンキーを含めたマカク属では一般に複数個のヘモグロビンが認められるが,この原因となるαグロビンの対立遺伝子あるいは遺伝子重複の点についても比較考察を加えた. / An adult bonnet monkey (Macaca radiata) was found to have three major hemoglobin components (Hb 1, Hb 2, and Hb 3) which were separated by carboxymethyl cellulose column chromatography. The α and β chains were isolated from Hb 3, and digested with trypsin. The tryptic peptides were isolated and sequenced by conventional methods. The alignment of these peptides in each chain was deduced from the homology of their sequences with those of human adult hemoglobin. The primary structures thus determined are compared with those of other primate hemoglobins.
Keywords: Hemoglobin / Amino acid sequence / Bonnet monkey
URI: http://hdl.handle.net/10069/18067
ISSN: 09160841
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 1

Citable URI : http://hdl.handle.net/10069/18067

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