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The Effect of X-irradiation on the Activation and Induction of Rat Liver Tryptophan Pyrrolase by Substrate and Hormone


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Title: The Effect of X-irradiation on the Activation and Induction of Rat Liver Tryptophan Pyrrolase by Substrate and Hormone
Authors: Atsuta, Joe / Okajima, Shunzo
Authors (alternative): 熱田, 襄 / 岡島, 俊三
Issue Date: Sep-1968
Publisher: 日本放射線影響学会
Citation: Journal of radiation research. 1968, 9(3-4), p.105-111
Abstract: The 500R whole body X-irradiation inhibited the increase in holotryptophan pyrrolase activity which were induced by the single administration of cortisone or L-tryptophan in the adrenalectomized rats. However, no inhibitory effect of X-irradiation was found in the activity of holo-tryptophan pyrrolase which was induced by the combined administration of cortisone and L-tryptophan. It was suggested that the radiation effect on holo-tryptophan pyrrolase formation in the cortisone induction was the result of inhibited conversion of apo-tryptophan pyrrolase to holo-tryptophan pyrrolase, whereas apo-tryptophan pyrrolase formation was scarcely affected by X-irradiation. On the other hand, in the tryptophan-induction an inhibition occurred in other processes, presumably in apo-tryptophan pyrrolase formation. The mechanism underlying the elimination of inhibitory effects of X-irradiation under the coexistance of cortisone and tryptophan was discussed.
URI: http://hdl.handle.net/10069/18809
ISSN: 04493060
Relational Links: http://ci.nii.ac.jp/naid/110002322927/
Rights: 日本放射線影響学会 / 本文データは学協会の許諾に基づきCiNiiから複製したものである
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/18809

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