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Sucralfate Protects Intestinal Epithelial Cells from Radiation-Induced Apoptosis in Rats

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Title: Sucralfate Protects Intestinal Epithelial Cells from Radiation-Induced Apoptosis in Rats
Authors: Matsuu-Matsuyama, Mutsumi / Shichijo, Kazuko / Okaichi, Kumio / Ishii, Kouji / Wen, Chung Yang / Fukuda, Eiichiro / Nakayama, Toshiyuki / Nakashima, Masahiro / Okumura, Yutaka / Sekine, Ichiro
Issue Date: 31-Mar-2006
Publisher: 日本放射線影響学会
Citation: Journal of radiation research. 2006, 47(1), p.1-8
Abstract: Radiotherapy for malignant pelvic disease is often followed by acute radiation colitis (ARC). It has been reported that sucralfate treatment has a protective effect against ARC, though the mechanisms of action are unknown. The effects of sucralfate on X-ray radiation-induced apoptosis was studied at 4 Gy in the colonic crypt cells of rats. Sucralfate enemas given prior to radiation resulted in the following: (1) reduction in number of apoptotic colonic crypt cells; (2) reduction in number of caspase-3 positive cells; (3) decreases in p53 accumulation and p21 expression; (4) decreases of Bax/Bcl-2 ratio. The protective effects of sucralfate against ARC may be partially due to the suppression of radiation-induced apoptosis by way of p53 in the colon and the protection of the colonic epithelial stem cell region.
Keywords: Radiation-induced apoptosis / Sucralfate / p53 / Rats / Intestine
URI: http://hdl.handle.net/10069/18812
ISSN: 04493060
Relational Links: http://ci.nii.ac.jp/naid/110004701145/
Rights: 日本放射線影響学会 / 本文データは学協会の許諾に基づきCiNiiから複製したものである
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/18812

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