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Differences in Effects of Oncogenes on Sensitivity to Anticancer Drugs


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Title: Differences in Effects of Oncogenes on Sensitivity to Anticancer Drugs
Authors: Hamamoto, Tomoyuki / Suzuki, Keiji / Sasaki, Hitoshi / Ichikawa, Masataka / Kodama, Seiji / Watanabe, Masami
Issue Date: 30-Jun-2005
Publisher: 日本放射線影響学会
Citation: Journal of radiation research. 2005, 46(2), p.197-203
Abstract: Methods to predict the responsiveness of a particular tumor to a particular anticancer drug are desirable not only for chemotherapy but also for chemoradiotherapy. Here, we examined the effects of viral or activated oncogenes on sensitivity to anticancer drugs by using SHOK (Syrian hamster Osaka-Kanazawa) cells and their transfectants. The IC_<50> of each transfectant was compared with that of the pSV2Neo transfected control. Cells transfected with the c-myc, v-mos, or v-fgr gene increased their sensitivity to bleomycin, while those transfected with the H-ras gene developed resistance. Resistance to cisplatin was conferred by the introduction of the H-ras or c-cot gene. In the case of adriamycin, the c-myc or c-cot transfectant increased sensitivity and the H-ras transfectant decreased it. Mitomycin C resistance was observed by the introduction of the K-ras gene. Thus, the H-ras gene was found to be involved in the development of resistance to three of the four anticancer drugs. In addition, we have for the first time shown that mos and cot have an effect on sensitivity to three and all of the four anticancer drugs, respectively. These results suggest that the expression of each oncogene would differently affect sensitivity to the four anticancer drugs used in this study, and this property could be a possible marker to predict chemosensitivity.
Keywords: Oncogene / SHOK cells / Chemosensitivity / IC_<50>
URI: http://hdl.handle.net/10069/18813
ISSN: 04493060
Relational Links: http://ci.nii.ac.jp/naid/110004041116/
Rights: 日本放射線影響学会 / 本文データは学協会の許諾に基づきCiNiiから複製したものである
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/18813

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