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Anti-Human T-Lymphotropic Virus Type-I Antibodies in Atomic-Bomb Survivors


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Title: Anti-Human T-Lymphotropic Virus Type-I Antibodies in Atomic-Bomb Survivors
Authors: Matsuo, Tatsuki / Nakashima, Eiji / Carter, Randolph L. / Neriishi, Kazuo / Mabuchi, Kiyohiko / Akiyama, Mitoshi / Shimaoka, Katsutaro / Kinoshita, Ken-Ichiro / Tomonaga, Masao / Ichimaru, Michito
Authors (alternative): 松尾, 辰樹
Issue Date: Mar-1995
Publisher: 日本放射線影響学会
Citation: Journal of radiation research. 1995, 36(1), p.8-16
Abstract: Adult T-cell leukemia (ATL), induced by human T-lymphotropic virus type-I (HTLV-I), is endemic in Nagasaki, Japan. To investigate the effects of atomic-bomb radiation on development of this specific type of leukemia, 6182 individuals in the Radiation Effects Research Foundation (RERE) Adult Health Study sample in Hiroshima and Nagasaki were examined for positive rate of HTLV-I antibody. Several lymphocyte parameters were also studied for 70 antibody-positive subjects in Nagasaki. The HTLV-I antibody-positive rate was higher in Nagasaki (6.36%) than in Hiroshima (0.79%) and significantly increased with increasing age, but no association was observed with radiation dose. Whether relationship existed between antibody titer levels and radiation dose among antibody-positive subjects was not clear. The frequency of abnormal lymphocytes tended to be higher in antibody-positive subjects than in antibody-negative subjects, and higher in females than in males regardless of radiation dose. Whether relationship existed between antibody titer levels and radiation dose among antibody-positive subjects was not clear. The frequency of abnormal lymphocytes tended to be higher in antibody-positive subjects than in antibody-negative subjects, and higher in females than in males regardless of radiation dose . The lymphocyte count was lower in antibody-positive subjects than in antibody-negative subjects and lower in female than in male subjects. No evidence was found to suggest that atomic-bomb radiation plays an important role in HTLV-1 infection.
Keywords: HTL V-I antibody / A-bomb survivors
URI: http://hdl.handle.net/10069/18885
ISSN: 04493060
Relational Links: http://ci.nii.ac.jp/naid/110002328064/
Rights: 日本放射線影響学会 / 本文データは学協会の許諾に基づきCiNiiから複製したものである
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/18885

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