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Atomic Bomb and Leukemia


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Title: Atomic Bomb and Leukemia
Authors: Ichimaru, M. / Tomonaga, M. / Amenomori, T. / Matsuo, T.
Issue Date: Dec-1991
Publisher: 日本放射線影響学会
Citation: Journal of radiation research. 1991, 32(Supple_2), p.14-19
Abstract: Characteristic features of the leukemia among atomic bomb survivors were studied. Dose estimates of atomic bomb radiation were based on T65D, but the new dosimetry system DS86 was used for some analyses. The ratio of a single leukemia type to all leukemias was highest for CML in Hiroshima, and the occurrence of CML was thought to be most characteristic to atomic bomb radiation induced leukemia. The threshold of CML occurrence in Hiroshima is likely to be between 0. 5-0. 09 Gy. However, the threshold of acute leukemia appears to be nearly 1 Gy. In the distribution of AML subtypes by FAB classification, there was no M3 case in 1 Gy or more group, although several atypical AML cases of survivors were observed. Although aplastic anemia has not increased as a late effect of the atomic bomb radiation exposure, many atypical leukemia or other myeloproliferative diseases who had been diagnosed as aplastic anemia or its related diseases have been experienced among atomic bomb survivors. Chromosome study was conducted using colony forming cells induced by hemopoietic stem cells of peripheral blood of proximal survivors. Same chromosome aberrations were observed in colony forming cells and peripheral T-cells in several atomic bomb survivors.
Keywords: CML, threshold / FAB classification / atypical leukemia / chromosome
URI: http://hdl.handle.net/10069/18909
ISSN: 04493060
Relational Links: http://ci.nii.ac.jp/naid/110002327945/
Rights: 日本放射線影響学会 / 本文データは学協会の許諾に基づきCiNiiから複製したものである
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/18909

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