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Inhibitory Activities of Proanthocyanidins from Persimmon against Oxidative Stress and Digestive Enzymes Related to Diabetes


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Title: Inhibitory Activities of Proanthocyanidins from Persimmon against Oxidative Stress and Digestive Enzymes Related to Diabetes
Authors: Lee, Young A / Cho, Eun Ju / Tanaka, Takashi / Yokozawa, Takako
Issue Date: Jun-2007
Publisher: 日本ビタミン学会
Citation: Journal of nutritional science and vitaminology, 53(3), p.287-292; 2007
Abstract: The present study was carried out to evaluate the promising potential of polymers and oligomers from proanthocyanidins of persimmon peel as antioxidants and therapeutic agents for diabetes. Both polymers and oligomers showed the scavenging effect of 2,2-diphenyl-1-picrylhydrazyl, with IC_<50> values of 4.35 and 2.41μg/mL, respectively, and they also showed a protective activity against protein oxidation induced by 2,2'-azobis (2-amidinopropane) dihydrochloride. In particular, oligomers exerted a stronger activity against free radicals than polymers. In addition, to investigate their protective potential against diabetes-related pathological conditions, their inhibitory activities on digestive enzymes and advanced glycation endproduct (AGE) formation were evaluated. Polymers showed a strong inhibitory activity against α-amylase, while oligomers had a relatively weak effect. This suggests that the inhibition of α-amylase activity would probably depend on the degree of polymerization. On the other hand, against α-glucosidase activity and AGE formation, oligomers exerted a stronger protective effect than polymers. The present study suggests that polymers and oligomers from proanthocyanidins of persimmon peel could play a role as antidiabetic agents with antioxidative effects. Moreover, oligomers rather than polymers from proanthocyanidins of persimmon peel may be expected to be a more promising antioxidative and antidiabetic agent in relation to utilization in biological systems.
Keywords: proanthocyanidins / oligomers / diabetes / antioxidant / persimmon
URI: http://hdl.handle.net/10069/18972
ISSN: 03014800
DOI: 10.3177/jnsv.53.287
Rights: 日本ビタミン学会
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/18972

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