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Establishment and Characterization of a Hypocatalasemic Mouse Cell Strain


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Title: Establishment and Characterization of a Hypocatalasemic Mouse Cell Strain
Authors: Utsumi, Hiroshi / Kodama, Seiji / Tano, Keizo / Hashimoto, Mitsumasa W. / Watanabe, Hiromitsu
Issue Date: Sep-1998
Publisher: 日本放射線影響学会
Citation: Journal of radiation research. 1998, 39(3), p.165-714
Abstract: Contact-inhibited catalase-deficient fibroblast cell strain has been established from the homozygous b hypocatalasemic C3H/Cs^b mutant mouse. This cell strain has low level of catalase enzyme activity and has normal level of enzyme activities of both glutathione peroxidase and superoxide dismutase. Catalase-deficient C3H/Cs^b mutant cell strain is markedly more sensitive to the toxicity of hydrogen peroxide compared to wild-type C3H/Cs^a cell strain. In addition, mutant cell strain is sensitive to X-rays and near-UV compared to wild-type cell strain, but shows the same sensitivities to topoisomerase II inhibitors, adriamycin and 4'-(9-acridinylamino) methanesulfon-m-anisidide (m-AMSA), and the DNA cross-linking agents, cis-diamminedichloroplatinum (II) (cis-Pt) and trans-diamminedichloroplatinum (II) (trans-Pt). These cell strains will be of use in the study of the roles which catalase plays in the intracellular prevention of DNA damage induced by oxidative stress.
Keywords: Hypocatalasemic mouse cell strain / Hydrogen peroxide / X-rays / Near-UV / Topoisomerase II inhibitor
URI: http://hdl.handle.net/10069/19027
ISSN: 04493060
Relational Links: http://ci.nii.ac.jp/naid/110002328148/
Rights: 日本放射線影響学会 / 本文データは学協会の許諾に基づきCiNiiから複製したものである
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/19027

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