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In vitro evaluation of atmospheric particulate matter and sedimentation particles using yeast bioassay system.


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タイトル: In vitro evaluation of atmospheric particulate matter and sedimentation particles using yeast bioassay system.
著者: Mori, Taiki / Inudo, Makiko / Takao, Yuji / Koga, Minoru / Takemasa, Takehiro / Shinohara, Ryota / Arizono, Koji
発行日: 2007年
出版者: MYU
引用: Environmental sciences, 14(4), pp.203-210; 2007
抄録: Little information on the evaluation of airborne particulate matter (APM) and sedimentation particles from subway stations is available. The thermal metamorphism of train wheels generating toxic particles in subway stations is a possibility. In this study, the toxicity and physiological effects of particles from subway stations were evaluated using a yeast bioassay system. Estrogenic and antiestrogenic activities of APM in APM extracts from subway stations were determined. No estrogenic activity was found in the APM fractions and their S9-activated APM samples. Sedimentation dust samples also showed no estrogen activity. In contrast, extracts from sedimentation dust samples showed antiestrogen activity. Marked yeast toxicity was observed in the samples extracted from sedimentation dust. Potent yeast toxicity was also found in the S9-activated extracts from sedimentation dust. The results suggest that sedimentation dust from a semiclosed area of a subway system has antiestrogen activity, although both the origin and generation system of this activity are uncertain. These pollutants in sedimentation dust may change to a more toxic form in vivo by S9 activation.
キーワード: APM / sedimentation dust / TDS-GC/MS / year two-hybrid assay
URI: http://hdl.handle.net/10069/20085
ISSN: 0915955X
PubMed ID: 17762843
関連リンク : http://www.myu-inc.jp/myukk/ES/
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:090 学術雑誌論文

引用URI : http://hdl.handle.net/10069/20085

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