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Limited allelic diversity of Plasmodium falciparum merozoite surface protein 1 gene from populations in the Solomon Islands.


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タイトル: Limited allelic diversity of Plasmodium falciparum merozoite surface protein 1 gene from populations in the Solomon Islands.
著者: Sakihama, Naoko / Ohmae, Hiroshi / Bakote'E, Bernard / Kawabata, Masato / Hirayama, Kenji / Tanabe, Kazuyuki
発行日: 2006年 1月
出版者: American Society of Tropical Medicine and Hygiene
引用: American Journal of Tropical Medicine and Hygiene, 74(1), pp.31-40; 2006
抄録: Meiotic recombination generates allelic diversity in the Plasmodium falciparum merozoite surface protein 1 (msp1) gene. In this study, we monitored recombination-based diversity of msp1 in Guadalcanal, the Solomon Islands, where malaria transmission is high. We identified 5' recombinant types, 3' sequence types, and msp1 haplotypes (unique associations of 5' recombinant types and 3' sequence types), and compared them with those from areas of low transmission in Thailand and Vanuatu. The mean number of 5' recombinant types per person (multiplicity) was lower in Guadalcanal than in Thailand. Guadalcanal populations had 6-8 msp1 haplotypes; the numbers are comparable to Vanuatu but much lower than in Thailand. There were marked geographic differences in distribution of msp1 haplo-types. Linkage disequilibrium in msp1 was stronger in Guadalcanal than in Thailand, suggesting limited recombination events in the Solomon Islands. We suggest that the frequency of recombination events in msp1 is determined not only by transmission intensity but by the number of msp1 alleles prevalent and multiplicity of infections.
URI: http://hdl.handle.net/10069/20113
ISSN: 00029637
PubMed ID: 16407343
関連リンク : http://www.ajtmh.org/cgi/content/abstract/74/1/31
権利: Copyright (c) 2006 by The American Society of Tropical Medicine and Hygiene
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:120 学術雑誌論文

引用URI : http://hdl.handle.net/10069/20113

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