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Molecular epidemiology of dengue 2 viruses in the Philippines: genotype shift and local evolution.

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タイトル: Molecular epidemiology of dengue 2 viruses in the Philippines: genotype shift and local evolution.
著者: Salda, Leonora T. D. / Parquet, Maria D. C. / Matias, Ronald R. / Natividad, Filipinas F. / Kobayashi, Noboyuki / Morita, Kouichi
発行日: 2005年10月
出版者: American Society of Tropical Medicine and Hygiene
引用: American Journal of Tropical Medicine and Hygiene, 73(4), pp.796-802; 2005
抄録: The pre-membrane (prM) and envelope (E) genes of 41 viruses isolated from dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS) patients from 1995 to 2002 were sequenced to determine the genetic variability of dengue 2 (DENV 2) viruses in the Philippines. The envelope sequence data were compared with a global sample of DENV 2 obtained from GenBank. Phylogenetic analysis revealed that two distinct genotypes, Asian 2 and Cosmopolitan, are currently circulating locally, each with the potential to cause severe hemorrhagic disease. After the initial isolation in 1998, the Cosmopolitan genotype has gradually and effectively replaced Asian genotype 2 in the Philippines. Members of this genotype were closely related to viruses from Australia, Singapore, and Thailand.
URI: http://hdl.handle.net/10069/20114
ISSN: 00029637
PubMed ID: 16222028
関連リンク : http://www.ajtmh.org/cgi/content/abstract/73/4/796
権利: Copyright (c) 2005 by The American Society of Tropical Medicine and Hygiene
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:120 学術雑誌論文

引用URI : http://hdl.handle.net/10069/20114



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