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Molecular epidemiology of dengue 2 viruses in the Philippines: genotype shift and local evolution.


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Title: Molecular epidemiology of dengue 2 viruses in the Philippines: genotype shift and local evolution.
Authors: Salda, Leonora T. D. / Parquet, Maria D. C. / Matias, Ronald R. / Natividad, Filipinas F. / Kobayashi, Noboyuki / Morita, Kouichi
Issue Date: Oct-2005
Publisher: American Society of Tropical Medicine and Hygiene
Citation: American Journal of Tropical Medicine and Hygiene, 73(4), pp.796-802; 2005
Abstract: The pre-membrane (prM) and envelope (E) genes of 41 viruses isolated from dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS) patients from 1995 to 2002 were sequenced to determine the genetic variability of dengue 2 (DENV 2) viruses in the Philippines. The envelope sequence data were compared with a global sample of DENV 2 obtained from GenBank. Phylogenetic analysis revealed that two distinct genotypes, Asian 2 and Cosmopolitan, are currently circulating locally, each with the potential to cause severe hemorrhagic disease. After the initial isolation in 1998, the Cosmopolitan genotype has gradually and effectively replaced Asian genotype 2 in the Philippines. Members of this genotype were closely related to viruses from Australia, Singapore, and Thailand.
URI: http://hdl.handle.net/10069/20114
ISSN: 00029637
PubMed ID: 16222028
Relational Links: http://www.ajtmh.org/cgi/content/abstract/73/4/796
Rights: Copyright (c) 2005 by The American Society of Tropical Medicine and Hygiene
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/20114

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