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In vitro reactivation of human immunodeficiency virus-1 upon stimulation with scrub typhus rickettsial infection.


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Title: In vitro reactivation of human immunodeficiency virus-1 upon stimulation with scrub typhus rickettsial infection.
Authors: Moriuchi, Masako / Tamura, Akira / Moriuchi, Hiroyuki
Issue Date: May-2003
Publisher: American Society of Tropical Medicine and Hygiene
Citation: American Journal of Tropical Medicine and Hygiene, 68(5), pp.557-561; 2003
Abstract: While a number of microbial infections induce a transient burst in viral load in individuals infected with human immunodeficiency virus-1 (HIV-1), a recent study has suggested that scrub typhus may suppress HIV-1 infection. We investigated the effects of Orientia tsutsugamushi on HIV-1 infection. In vitro HIV-1 infection experiments were conducted using peripheral blood mononuclear cells (PBMC) acutely infected with R5 and X4 HIV-1 or PBMC derived from patients receiving highly active antiretroviral therapy (HAART) whose plasma viral load was undetectable. Stimulation of PBMC with O. tsutsugamushi induced production of proinflammatory cytokines and {beta}-chemokines, and markedly down-regulated expression of CCR5. Although pretreatment with O. tsutsugamushi rendered PBMC resistant to R5 HIV-1, it otherwise enhanced HIV-1 replication. Stimulation by O. tsutsugamushi induced HIV-1 replication in PBMC from patients receiving HAART. These findings suggest that scrub typhus does not necessarily suppress HIV-1 infection and does have potential to enhance HIV-1 replication.
URI: http://hdl.handle.net/10069/20126
ISSN: 00029637
PubMed ID: 12812345
Relational Links: http://www.ajtmh.org/cgi/content/abstract/68/5/557
Rights: Copyright (c) 2003 by The American Society of Tropical Medicine and Hygiene
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/20126

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