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肺癌におけるGST-πとメタロチオネインの発現


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Title: 肺癌におけるGST-πとメタロチオネインの発現
Other Titles: Expression of Glutathione S-transferase-pi (GST-pi)and Metallothionein (MT)in Lung Cancer
Authors: 藤野, 了 / 坂本, 晃 / 福田, 実 / 高谷, 洋 / 福田, 正明 / 早田, 宏 / 井上, 祐一 / 木下, 明敏 / 岡, 三喜男 / 河野, 茂
Authors (alternative): Fujino, Satoru / Sakamoto, Akira / Fukuda, Minoru / Takatani, Hiroshi / Fukuda, Masaaki / Soda, Hiroshi / Inoue, Yuichi / Kinoshita, Akitoshi / Oka, Mikio / Kohno, Shigeru
Issue Date: 20-Apr-1997
Publisher: 日本肺癌学会
Citation: 肺癌 = Japanese Journal of Lung Cancer, 37(2), p.135-141; 1997
Abstract: 細胞内解毒酵素であるグルタチオンS一トランスフェラーゼπ(GST一π)やメタロチオネイン(MT)が癌細胞の抗癌剤耐性に関与していることが実験的に示唆されている.本研究では, GST一πとMTの発現を手術肺癌97例で免疫組織染色にて分析し, 化学療法との関係を検討した.GST一πは未治療の非小細胞肺癌56例て86%陽性と小細胞肺癌より有意に発現が高かった(P<0.0001).未治療の小細胞肺癌8例すべて陰性, シスプラチンを含む化学療法を行った18例の小細胞肺癌で78%陽性と有意に化学療法により誘導された(P=0.0003).MTは未治療の非小細胞肺癌56例で28%陽性, 治療の非小細胞肺癌15例で80%陽性と有意に化学療法により誘導された(P=0.0005).非小細胞肺癌の腫瘍マーカーとしてGST一πは有用であり, 小細胞肺癌で治療により有意にGST一πが誘導され薬剤耐性に関与し, 非小細胞肺癌で治療により有意にMTが誘導され薬剤耐性に関与すると考える. / It has been suggested that glutathione S-transferase-pi (GST-π) and metallothionein (MT), which are an intracellular detoxification enzyme and detoxification protein, are contribute to anti-cancer drug resistance. In present study, GST-π and MT expression was analyzed immunohistochemically in primary tumors from 97 patients with lung cancer and the relationship with the results of chemotherapy was examined. Of 56 previously untreated non-small cell lung cancer, 86% were positive for GST-π, which was significantly higher than the degree for small cell lung cancer (P<0.0001). All 8 previously untreated small cell lung cancer were negative for GST-π and 78% of 18 small cell lung cancer cases receiving preoperative chemotherapy with a regimen including cisplatin were positive. GST-π was found to be induced after chemotherapy (P=0.0003). Of 56 previously untreated non-small cell lung cancers 27% were positive for MT and 80% of 15 non-small cell lung cancer received preoperative chemotherapy were positive. MT was significantly induced after chemotherapy(P=0.0005). We therefore suggest that GSTπ is an important tumor marker of non-small cell lung cancer, which is significantly induced after chemotherapy and related to drug resistance.
Keywords: Glutathione s-transferase-π / Metallothionein / Lung cancer / Drug resistance / Chemotherapy
URI: http://hdl.handle.net/10069/20242
ISSN: 03869628
Relational Links: http://ci.nii.ac.jp/naid/110003123540/
Rights: 日本肺癌学会 / 本文データは学協会の許諾に基づきCiNiiから複製したものである
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/20242

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