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非小細胞肺癌に対する術後補助化学療法の検討 : 第2次研究 : CDDP+VDS+UFT投与群とUFT単独投与群と手術単独群の比較試験


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Title: 非小細胞肺癌に対する術後補助化学療法の検討 : 第2次研究 : CDDP+VDS+UFT投与群とUFT単独投与群と手術単独群の比較試験
Other Titles: A Randomized Controlled Postoperative Adjuvant Chemotherapy Trial of CDDP+VDS+UFT and UFT Alone in Comparison with Operation Only for Non-Small Cell Lung Carcinomas : Second Study
Authors: 富田, 正雄 / 綾部, 公懿 / 川原, 克信 / 寺松, 孝
Authors (alternative): Tomita, Masao
Issue Date: 20-Jun-1994
Publisher: 日本肺癌学会
Citation: 肺癌 = Japanese Journal of Lung Cancer, 34(3), p.297-306; 1994
Abstract: 西日本肺癌手術の補助化学療法研究会では第2次研究として, 非小細胞肺癌の治癒切除ないし相対的非治癒切除後の術後補助化学療法としてCDDP+VDS+UFT投与群(A群)109例とUFT単独投与群(B群)103例を手術単独群(C群)98例と術後3年の生存率を中心に比較検討した.1)全症例の3年生存率はA群71.2%, B群74.6%, C群62.2%で, C群の手術単独群に比しA群, B群ともに良好な成績であり, 補助化学療法施行群の生存率が向上する傾向がみられた.2)根治度別では相対的治癒切除例, 病期分類ではStageIIIA, 組織型では腺癌において, C群に比し, A, B群で良好な成績で, 3群間およびBC群問に有意差が認められた.3)3年経過後の再発率はA群32.1%, B群32.0%, C群37.0%で, C群に比しA, B群の再発率は低かった.以上より手術単独群に比し薬剤投与群の成績が明らかに良好であり, UFT単独による術後補助化学療法の有用性も示唆された. / A multi-institutional cooperative study was carried out in Western Japan to examine the survival periods and side effects of postoperative adjuvant chemotherapy between CDDP+VDS+UFT and UFT, in which curatively or relatively non-curatively resected patients were randomized. The effects and validity of postoperative adjuvant chemotherapy were evaluated in terms of the 3-year survival rate as compared with those of operation only. 1) A satisfactory 3-year survival rate was obtained in both groups in which postoperative adjuvant chemotherapy was performed compared with the operation-only group. 2) Postoperative adjuvant chemotherapy was effective in stage IIIA, in cases of adenocarcinoma in which relatively curative surgery was performed. 3) Recurrence rates 3 years after surgery were lower with postoperative adjuvant chemotherapy as compared with operation only. In particular recurrence was lowest in the UFT group. Thus, postoperative results were better in patients who received adjuvant chemotherapy. Postoperative adjuvant chemotherapy using UFT alone was also effective.
Keywords: Non-small cell lung carcinoma / Adjuvant chemotherapy / UFT
URI: http://hdl.handle.net/10069/20262
ISSN: 03869628
Relational Links: http://ci.nii.ac.jp/naid/110003113552/
Rights: 日本肺癌学会 / 本文データは学協会の許諾に基づきCiNiiから複製したものである
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/20262

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