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タイトル: 遅延性DNA損傷の誘発と遺伝的不安定性
その他のタイトル: Delayed DNA damage and radiation-induced genomic instability
著者: 鈴木, 啓司 / 児玉, 靖司 / 渡邉, 正己
著者(別表記) : Suzuki, Keiji / Kodama, Seiji / Watanabe, Masami
発行日: 2005年 7月
出版者: 日本環境変異原学会
引用: 環境変異原研究, 27(2), pp. 111-115; 2005
抄録: Ionizing radiation induces genomic instability, which is transmitted through many generations after irradiation in the progeny of surviving cells. We have hypothesized that radiation-induced large deletion causes potentially unstable chromosome regions, which are involved in delayed induction of radiation-induced genomic instability. Using phosphorylation-specific antibodies against ATM and histone H2AX, whose phosphorylation is induced by DNA double strand breaks, we detected delayed induction of phosphorylated ATM and H2AX foci in the progeny of X-ray-surviving cells, which indicated delayed induction of DNA double strand breaks. Furthermore, we found delayed chromosomal instability in X chromosomes in clones which contain large deletion involving the HPRT loci. It is suggested that large deletion involving ~Mb region causes unstable chromatin structure, and it results in delayed rearrangement of chromosomes involved. These findings provide the possibility that manifestation of radiation-induced genomic instability results from delayed DNA breaks, i.e., the breaks lead to delayed chromosome rearrangements, delayed cell death etc., many generations after irradiation.
キーワード: radiation / genome / instability / DNA damage / chromatin
URI: http://hdl.handle.net/10069/20815
ISSN: 09100865
関連リンク : http://ci.nii.ac.jp/naid/110001789612/
権利: 日本環境変異原学会 / 本文データは学協会の許諾に基づきCiNiiから複製したものである
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:115 学術雑誌論文

引用URI : http://hdl.handle.net/10069/20815



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