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Interferon regulatory factor 4 differentially regulates the production of Th2 cytokines in naive vs. effector/memory CD4+ T cells.


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Title: Interferon regulatory factor 4 differentially regulates the production of Th2 cytokines in naive vs. effector/memory CD4+ T cells.
Authors: Honma, Kiri / Kimura, Daisuke / Tominaga, Norio / Miyakoda, Mana / Matsuyama, Toshifumi / Yui, Katsuyuki
Issue Date: 14-Oct-2008
Publisher: National Academy of Sciences
Citation: Proceedings of the National Academy of Sciences of the United States of America, 105(41), pp.15890-15895; 2008
Abstract: Interferon regulatory factor (IRF) 4 is a member of the IRF family of transcription factors and plays critical roles in the development of CD4(+) T cells into Th2 and Th17 cells. Using the infection model of Nippostrongyrus brasiliensis, we have confirmed the critical roles of IRF-4 in Th2 development in vivo by using IRF-4(-/-) BALB/c mice. However, naïve IRF-4(-/-)CD4(+) T cells produced Th2 cytokines, including IL-4, IL-5, and IL-10, but not IL-2 or IFN-gamma, at levels higher than wild-type BALB/c CD4(+) T cells in response to T cell receptor stimulation. In contrast, effector/memory IRF-4(-/-)CD4(+) T cells did not exhibit increased production of Th2 cytokines. Knockdown of IRF-4 expression by using small interfering RNA promoted IL-4 production in naïve CD4(+) T cells but inhibited it in effector/memory CD4(+) T cells. These results indicate that IRF-4 plays differential roles in the regulation of Th2 cytokine production in naïve CD4(+) T cells and effector/memory CD4(+) T cells. IRF-4 inhibits Th2 cytokine production in naïve CD4(+) T cells, whereas it promotes Th2 cytokine production in effector/memory CD4(+) T cells.
Keywords: IL-4 / Nippostrongyrus brasiliensis / siRNA
URI: http://hdl.handle.net/10069/20853
ISSN: 00278424
DOI: 10.1073/pnas.0803171105
PubMed ID: 18836070
Rights: (c) 2008 by The National Academy of Sciences of the USA
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/20853

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