DSpace university logo mark
詳細検索
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > 110 医歯薬学総合研究科 > 110 学術雑誌論文 >

Interferon regulatory factor 4 differentially regulates the production of Th2 cytokines in naive vs. effector/memory CD4+ T cells.


ファイル 記述 サイズフォーマット
PNAS105_15890.pdf本文378.24 kBAdobe PDF本文ファイル
PNAS105_15890_SuppInfo.pdfサポート情報353.67 kBAdobe PDF本文ファイル

タイトル: Interferon regulatory factor 4 differentially regulates the production of Th2 cytokines in naive vs. effector/memory CD4+ T cells.
著者: Honma, Kiri / Kimura, Daisuke / Tominaga, Norio / Miyakoda, Mana / Matsuyama, Toshifumi / Yui, Katsuyuki
発行日: 2008年10月14日
出版者: National Academy of Sciences
引用: Proceedings of the National Academy of Sciences of the United States of America, 105(41), pp.15890-15895; 2008
抄録: Interferon regulatory factor (IRF) 4 is a member of the IRF family of transcription factors and plays critical roles in the development of CD4(+) T cells into Th2 and Th17 cells. Using the infection model of Nippostrongyrus brasiliensis, we have confirmed the critical roles of IRF-4 in Th2 development in vivo by using IRF-4(-/-) BALB/c mice. However, naïve IRF-4(-/-)CD4(+) T cells produced Th2 cytokines, including IL-4, IL-5, and IL-10, but not IL-2 or IFN-gamma, at levels higher than wild-type BALB/c CD4(+) T cells in response to T cell receptor stimulation. In contrast, effector/memory IRF-4(-/-)CD4(+) T cells did not exhibit increased production of Th2 cytokines. Knockdown of IRF-4 expression by using small interfering RNA promoted IL-4 production in naïve CD4(+) T cells but inhibited it in effector/memory CD4(+) T cells. These results indicate that IRF-4 plays differential roles in the regulation of Th2 cytokine production in naïve CD4(+) T cells and effector/memory CD4(+) T cells. IRF-4 inhibits Th2 cytokine production in naïve CD4(+) T cells, whereas it promotes Th2 cytokine production in effector/memory CD4(+) T cells.
キーワード: IL-4 / Nippostrongyrus brasiliensis / siRNA
URI: http://hdl.handle.net/10069/20853
ISSN: 00278424
DOI: 10.1073/pnas.0803171105
PubMed ID: 18836070
権利: (c) 2008 by The National Academy of Sciences of the USA
資料タイプ: Journal Article
原稿種類: author
出現コレクション:110 学術雑誌論文

引用URI : http://hdl.handle.net/10069/20853

このリポジトリに保管されている文献はすべて著作権により保護されています。
印刷やダウンロード等データの複製は、調査研究・教育または学習を目的とする場合に限定されます。

 

Valid XHTML 1.0! Copyright © 2006-2015 長崎大学附属図書館 - お問い合わせ Powerd by DSpace