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Protection by Polaprezinc Against Radiation-Induced Apoptosis in Rat Jejunal Crypt Cells


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Title: Protection by Polaprezinc Against Radiation-Induced Apoptosis in Rat Jejunal Crypt Cells
Authors: Matsuu-Matsuyama, Mutsumi / Shichiji, Kazuko / Okaichi, Kumio / Nakayama, Toshiyuki / Nakashima, Masahiro / Uemura, Takashi / Niino, Daisuke / Sekine, Ichiro
Issue Date: Jul-2008
Publisher: 日本放射線影響学会 / THE JAPAN RADIATION RESEARCH SOCIETY
Citation: Journal of Radiation Research, 49(4), pp.341-347; 2008
Abstract: Polaprezinc, an anti-ulcer drug, is a chelate compound consisting of zinc and L-carnosine. Polaprezinc has been shown to prevent gastric mucosal injury. The anti ulcer effects of polaprezinc have been ascribed to its antioxidative property. The effect of polaprezinc on ionizing radiation-induced apoptosis was studied in the jejunal epithelial crypt cells of rats. Seven-to eight week-old Wistar rats, which were treated with 100 mg/kg of polaprezinc orally 1h before irradiation or 2% carboxymethyl cellulose sodium in controls, were exposed to whole body X-ray irradiation at 2 Gy. The number of apoptotic cells per jejunum crypt was counted in haematoxylin and eosin stained sections at 0-6 h after irradiation. TUNEL positive cells and immunopositive cells for active caspase-3 per crypt were also counted. Accumulation of p53, p21^<WAF1/CIP1> and Bax expression in the jejunum after irradiation were examined by Western blot analyses. Polaprezinc treatment given prior to radiation resulted in a significant reduction in numbers of apoptotic cells, TUNEL positive cells and active caspase-3 immunopositive cells in jejunal crypt cells. Polaprezinc treatment resulted in decreases of p53 accumulation, p21^<WAF1/CIP1> and Bax expression after irradiation. Polaprezinc has a protective effect against ionizing radiation induced apoptosis in rat jejunal crypt cells.
Keywords: Radiation-induced apoptosis / Polaprezinc / p53 / Rats / Intestine
URI: http://hdl.handle.net/10069/20895
ISSN: 04493060
DOI: 10.1269/jrr.07114
Relational Links: http://ci.nii.ac.jp/naid/110006820173/
Rights: Copyright (c) 2008 by THE JAPAN RADIATION RESEARCH SOCIETY / 本文データは学協会の許諾に基づきCiNiiから複製したものである
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/20895

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