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Relationship between period of survival and clinicopathological characteristics in patients with colorectal liver metastasis

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Title: Relationship between period of survival and clinicopathological characteristics in patients with colorectal liver metastasis
Authors: Nanashima, Atsushi / Araki, M / Tobinaga, Syuichi / Kunizaki, Masaki / Hidaka, Shigekazu / Shibata, K / Mochinaga, Kouji / Sawai, T / Isomoto, Hajime / Ohnita, Ken / Uehara, M / Nagayasu, Takeshi
Issue Date: 22-Jan-2009
Publisher: Elsevier B.V.
Citation: European Journal of Surgical Oncology, 35(5), pp.504-509; 2009
Abstract: AIM: Cancer death in the early period after hepatectomy still occurs in patients with colorectal liver metastasis (CLM). We examined the relationship between clinicopathological parameters and survival periods in 130 CLM patients who underwent hepatectomy. PATIENTS/METHODS: Patients were divided into four groups: Group 1 (5-year survivors without tumor relapse), Group 2 (survivors at 2-5years), Group 3 (cancer death at 2-5years), and Group 4 (cancer death within 2years). RESULTS: A short surgical margin was frequent in Group 4 compared to Group 1 (31 vs. 78%, P<0.05). Primary node-positive status, absence of fibrous pseudo-capsular formation, higher Clinical Risk Score, and tumor recurrence within 12months were frequent in Group 4 (P<0.05). Multivariate analysis revealed a short surgical margin (HR; 3.5) and early tumor relapse (HR; 5.9) as independently significant related parameters (P<0.05). CONCLUSIONS: Sufficient surgical margins and careful follow-up for early tumor relapse may be important for improving postoperative outcomes for CLM patients.
Keywords: Colorectal carcinoma / Liver metastasis / Hepatectomy / Prognosis / Surgical margin
URI: http://hdl.handle.net/10069/20902
ISSN: 15322157
DOI: 10.1016/j.ejso.2009.01.001
PubMed ID: 19167860
Rights: Copyright © 2008 Elsevier B.V. All rights reserved.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/20902

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