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温熱負荷方法の違いがラットヒラメ筋の廃用性筋萎縮の進行抑制におよぼす影響 : 温水浴と電気熱プレートの比較

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Title: 温熱負荷方法の違いがラットヒラメ筋の廃用性筋萎縮の進行抑制におよぼす影響 : 温水浴と電気熱プレートの比較
Other Titles: Effects of Differences in Heating Methods on Inhibiting the Progression of Disuse Muscle Atrophy in Rat Soleus Muscle : Comparison of a Warm Water Bath and Electrical Heating Plate
Authors: 渡部, 由香 / 吉川, 紗智 / 片岡, 英樹 / 片岡, 紀香 / 坂本, 淳哉 / 中野, 治郎 / 沖田, 実
Authors (alternative): Watanabe, Yuka / Yoshikawa, Sachi / Kataoka, Hideki / Kataoka, Norika / Sakamoto, Junya / Nakano, Jiro / Okita, Minoru
Issue Date: 20-Dec-2006
Publisher: 社団法人日本理学療法士協会
Citation: 理学療法学. 33(7), p.355-362: 2006
Abstract: 本研究の目的は,温水浴と電気熱プレートによるラットヒラメ筋の廃用性筋萎縮の進行抑制効果を比較検討することである。Wistar系雄ラット22匹を対照群4匹と7日間の後肢懸垂(HS)によりヒラメ筋に廃用性筋萎縮を惹起させる実験群18匹に分け,実験群はさらに,1)HSのみの群(HS群;n=6),2)HSの過程で下半身の温水浴により温熱を負荷する群(HS & Heat-Bath群;n=6),3)HSの過程で電気熱プレートにより温熱を負荷する群(HS & Heat-Plate群;n=6)に分けた。温熱負荷は麻酔下で毎日60分間,7日間継続して行い,両方法とも負荷温度は42℃とした。実験終了時の体重ならびに体重変化率を比較するとHS & Heat-Bath群のみ顕著に減少していた。そして,ヒラメ筋の相対重量比やタイプI・II線維の筋線維直径はHS & Heat-Bath群,HS & Heat-Plate群ともにHS群より有意に高値で,HS & Heat-Plate群のタイプI線椎の筋線維直径はHS & Heat-Bath群のそれより有意に高値を示した。また,熱ショックタンパク質(HSP)70含有量はHS & Heat-Bath群,HS & Heat-Plate群ともにHS群より有意に高値で,この2群間には有意差を認めなかった。以上のことより,電気熱プレートといった局所的な温熱負荷の方法でも,骨格筋にHSP70を誘導することは可能で,全身への影響を考えると温水浴よりも廃用性筋萎縮の予防方法として有用ではないかと考えられた。 / The current research sought to study the effects of a warm water bath and electrical heating plate on inhibiting the progression of disuse muscle atrophy of the rat soleus muscle. Twenty-two Wistar male rats were divided into a control group of 4 rats and a test group of 18 rats in which disuse muscle atrophy was induced in the soleus muscle through 7 days of hindlimb suspension (HS). The test group was further divided into 1) a group that underwent HS alone (HS group; n=6), 2) a group that had its lower body heated with a warm water bath in the course of HS (HS & Heat-Bath group; n=5), and 3) a group heated with an electrical heating plate in the course of HS (HS & Heat-Plate group; n=4). Heating lasted for 60 minutes a day under anesthesia and was continued for 7 days. With both methods of heating, the load temperature was 42℃. Comparison of body weight at the start and upon completion of the experiment indicated that the weight decreased markedly only for the HS & Heat-Bath group. Additionally, the relative weight ratio of soleus muscle and muscle fiber diameter of type I and II fiber was significantly greater in both the HS & Heat-Bath group and HS & Heat-Plate group than the HS group, and the muscle fiber diameter of type I fiber in the HS & Heat-Plate group was significantly greater than that in the HS & Heat-Bath group. In addition, heat shock protein (HSP) 70 content was significantly higher in both the HS & Heat-Bath group and HS & Heat-Plate group than the HS group, but the difference between these 2 groups was not significant. Based on these findings, even local heating, i.e. with an electrical heating plate, may induce HSP70 in skeletal muscle. Given its effects on the entire body, this form of heating may be more effective as a method of preventing disuse muscle atrophy than a warm water bath.
Keywords: 温熱負荷方法 / 廃用性筋萎縮 / Heat shock protein 70
URI: http://hdl.handle.net/10069/21266
ISSN: 02893770
Relational Links: http://ci.nii.ac.jp/naid/110006153528/
Rights: 社団法人日本理学療法士協会 / 本文データは学協会の許諾に基づきCiNiiから複製したものである
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/21266

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