DSpace university logo mark
Advanced Search
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > Faculty of Environmental Science > Bulletin > Journal of environmental studies, Nagasaki University > Special Issue Celebrating Ten Years Of Establishment Of Faculty Of Environmental Studies >

In Vivo Evaluation of 4-Methyl-2, 4-bis(4-hydroxyphenyl) pent-1-ene (MBP), a Bisphenol A Metabolite, Using the Nematode Caenorhabditis elegans(SPECIAL ISSUE CELEBRATING TEN YEARS OF ESTABLISHMENT OF FACULTY OF ENVIRONMENTAL STUDIES)


File Description SizeFormat
KJ00005072988.pdf421.97 kBAdobe PDFView/Open

Title: In Vivo Evaluation of 4-Methyl-2, 4-bis(4-hydroxyphenyl) pent-1-ene (MBP), a Bisphenol A Metabolite, Using the Nematode Caenorhabditis elegans(SPECIAL ISSUE CELEBRATING TEN YEARS OF ESTABLISHMENT OF FACULTY OF ENVIRONMENTAL STUDIES)
Other Titles: In Vivo Evaluation of 4-Methyl-2, 4-bis(4-hydroxyphenyl) pent-1-ene (MBP), a Bisphenol A Metabolite, Using the Nematode Caenorhabditis elegans(SPECIAL ISSUE CELEBRATING TEN YEARS OF ESTABLISHMENT OF FACULTY OF ENVIRONMENTAL STUDIES)
Authors: Kohra, Shinya / Inoue, Daisuke / Yamaguchi, Akemi / Takao, Yuji / Tominaga, Nobuaki / Arizono, Koji / Ueda, Kazuo
Issue Date: Aug-2007
Citation: 長崎大学総合環境研究. 2007, 環境科学部創立10周年記念特別号, p. 1-6
Abstract: In this study, we investigated the lethal and sublethal effects of 4-methyl-2 ,4-bis(4-hydroxyphenyl)-pent-l-ene (MBP), a bisphenol A (BPA) metabolite, using the nematode Caenorhabditis eleganas (C. elegans) grown on Nematode Growth Medium (NGM) 1.7% agar plates. The bioconcentration factor (BCF) was also determined. The 24 hr-median lethal concentration (24 hr-LC_<50>) value of MBP was 0.49 mM (134 mg/1), and the acute toxicity of MBP against C. elegans was slightly stronger than that of BPA. In contrast to BPA, the sublethal toxicity of MBP in a multi-generation test, as determined by reproduction and fecundity, was slightly lower. The growth of animals, as determined by body lenth, was enhanced by 3-8% at 0.1 mM MBP, after 48-72 hr. The BCF value after exposure for 48 hr was determined to be approximately 19-105 as compared with the nominal concentration.
Keywords: Caenorhabditis elegans / metabolite / bisphenol A / bioconcentration factor
URI: http://hdl.handle.net/10069/21456
ISSN: 13446258
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Special Issue Celebrating Ten Years Of Establishment Of Faculty Of Environmental Studies

Citable URI : http://hdl.handle.net/10069/21456

All items in NAOSITE are protected by copyright, with all rights reserved.

 

Valid XHTML 1.0! Copyright © 2006-2015 Nagasaki University Library - Feedback Powerd by DSpace