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The Effects of γ-tocopherol Administration on Pretibial Edema in Young Women with Premenstrual Syndrome


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タイトル: The Effects of γ-tocopherol Administration on Pretibial Edema in Young Women with Premenstrual Syndrome
著者: Kato, Shigeko / Shiraishi, Keiko / Koshida, Sayo / Mune, Masatoshi / Omagari, Katsuhisa
発行日: 2009年 3月
引用: Acta medica Nagasakiensia, 53(3), pp.59-64 ; 2009
抄録: Gamma-tocopherol is largely metabolized to 2,7,8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman (γ-CEHC), which has natriuretic activity that is mediated via inhibition of 70 pS ATP-sensitive K+ channels in the thick ascending limb of the loop of Henle. However, the effects of γ-tocopherol administration on edema are unclear. To determine the effects of γ-tocopherol administration on pretibial edema, we measured urinary γ-CEHC concentration by high-performance liquid chromatography with electrochemical detection (HPLC-ECD) after administration of γ-tocopherol. Twenty young women who had a history of pretibial edema due to premenstrual syndrome were randomly divided into two groups. The γ-tocopherol group received 4 "γ-tocopherol capsules" (each containing 100mg of γ-tocopherol), and the control group received 4 "placebo capsules" (each containing 250mg of soybean oil) per day for 7 days. Urinary sodium and potassium secretion and urine volume did not increase after cessation of γ-tocopherol administration, yet the degree of pretibial edema improved in all participants in the γ-tocopherol group. The serum γ-tocopherol concentration significantly increased in the γ-tocopherol group. Urinary excretion of γ-CEHC significantly increased after γ-tocopherol administration. Our results suggest that orally administered γ-tocopherol on renal sodium handling is not apparent, but γ-tocopherol is a precursor of prolonged natriuresis of γ-CEHC and may be effective for edema.
キーワード: γ-tocopherol / γ-CEHC / Premenstrual syndrome / Edema / HPLC
URI: http://hdl.handle.net/10069/21499
ISSN: 00016055
関連リンク : http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/53.59
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 53, No. 3

引用URI : http://hdl.handle.net/10069/21499

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