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Melting curve analysis for rapid detection of topoisomerase gene mutations in Haemophilus influenzae.


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Title: Melting curve analysis for rapid detection of topoisomerase gene mutations in Haemophilus influenzae.
Authors: Nakamura, Shigeki / Yanagihara, Katsunori / Morinaga, Yoshitomo / Izumikawa, Koichi / Seki, Masafumi / Kakeya, Hiroshi / Yamamoto, Yoshihiro / Kamihira, Shimeru / Kohno, Shigeru
Issue Date: Mar-2009
Publisher: American Society for Microbiology
Citation: Journal of Clinical Microbiology, 47(3), pp.781-784; 2009
Abstract: We established a real-time PCR assay with melting curve analysis to rapidly genotype quinolone resistance-determining regions (QRDRs) of gyrase A and topoisomerase IV genes in Haemophilus influenzae. This assay is a useful tool for the detection of fluoroquinolone resistance and for the early detection of preexisting QRDR mutations.
URI: http://hdl.handle.net/10069/21639
ISSN: 1098660X / 00951137
DOI: 10.1128/JCM.01645-08
PubMed ID: 19129413
Rights: Copyright © 2009, American Society for Microbiology. All Rights Reserved.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/21639

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