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Biological Significance of DNA Damage Checkpoint and the Mode of Checkpoint Signal Amplification

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Title: Biological Significance of DNA Damage Checkpoint and the Mode of Checkpoint Signal Amplification
Authors: Yamauchi, Motohiro / Suzuki, Keiji / Yamashita, Shunichi
Issue Date: Mar-2009
Citation: Acta medica Nagasakiensia, 53(supl.), pp.3-5 ; 2009
Abstract: It is generally accepted that DNA damage checkpoint is the mechanism that allows time for DNA damage repair. However, several lines of evidence challenge this paradigm, especially, in the case of G1 checkpoint. The first evidence is the complete difference between the repair kinetics of DNA double-strand breaks (very rapid) and the timing of G1 checkpoint induction (very slow) after ionizing radiation. The second evidence is that inactivation of p53, which is a central player of G1 checkpoint, does not render cells radiosensitive, rather, such cells become radioresistant. Moreover, it was shown that G1 arrest persists almost permanently after irradiation, until the time when most of the initial damage should be repaired and disappear. Therefore, cells should have a mechanism to maintain G1 checkpoint signaling by amplifying the signal from a limited number of damage. In this review, we discuss what is the bona fide role of G1 arrest and how G1 checkpoint signal is maintained long after irradiation.
Keywords: Checkpoint / Repair / DNA double-strand breaks
URI: http://hdl.handle.net/10069/21791
ISSN: 00016055
Relational Links: http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/53.S3
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 53, Supplement

Citable URI : http://hdl.handle.net/10069/21791

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