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Expression and DNA microarray analysis of a platelet activating factor-related molecule in severe pneumonia in mice due to influenza virus and bacterial co-infection.


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Title: Expression and DNA microarray analysis of a platelet activating factor-related molecule in severe pneumonia in mice due to influenza virus and bacterial co-infection.
Authors: Seki, Masafumi / Kosai, Kosuke / Hara, Atsuko / Imamura, Yoshifumi / Nakamura, Shigeki / Kurihara, Shintaro / Izumikawa, Koichi / Kakeya, Hiroshi / Yamamoto, Yoshihiro / Yanagihara, Katsunori / Miyazaki, Yoshitsugu / Mukae, Hiroshi / Tashiro, Takayoshi / Kohno, Shigeru
Issue Date: Jan-2009
Publisher: National Institute of Infectious Diseases
Citation: Japanese Journal of Infectious Diseases, 62(1), pp.6-10; 2009
Abstract: Platelet-activating factor (PAF) is a critical mediator of severe inflammatory diseases such as pneumonia, and the PAF-receptor (PAFR) is known to be an anchor for Streptococcus pneumoniae attachment to lung epithelial cells. We conducted a DNA microarray analysis to detect critical factors that mediate fulminant pneumonia due to influenza virus and S. pneumoniae co-infection in mice. Among the factors detected, levels of PAF-acetyl hydrolase (PAF-AH), which functions as inactivated PAF, were significantly increased, and PAFR was expressed in co-infected mouse lungs, as compared to the respective levels in mice infected with either S. pneumoniae or virus alone. Significantly elevated PAF-AH enzymatic activity was observed in the co-infected mouse lung, suggesting that co-infection activated PAF-related factors. These findings suggest that PAF and related molecules play important roles in fulminant pneumonia due to influenza virus infection, especially when severe bacterial pneumonia is complicated by co-infection with influenza virus.
URI: http://hdl.handle.net/10069/21809
ISSN: 13446304
PubMed ID: 19168951
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/21809

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