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Eosinophil Hyporesponse of Jirds Induced by Microfilariae of Brugia Pahangi


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Title: Eosinophil Hyporesponse of Jirds Induced by Microfilariae of Brugia Pahangi
Authors: Horii, Yoichiro / Nakanishi, Hirokuni / Mori, Akio / Zaitsu, Makoto / Ueda, Masakatsu / Kurokawa, Kenji / Oda, Tsutomu / Fujita, Koichiro
Issue Date: Aug-1989
Publisher: American Society of Tropical Medicine and Hygiene
Citation: American Journal of Tropical Medicine and Hygiene, 41(2), pp.183-188; 1989
Abstract: Male jirds (Meriones unguiculatus) were inoculated sc with 100 infective larvae of Brugia pahangi. After 16 weeks, the animals were reinoculated with a comparable number of organisms. Blood eosinophil responses during the 5 weeks subsequent to this attempt to reinfect were much lower than those of comparable naive animals, while the response to a heterologous infection (Toxocara canis) was comparable to that of controls. Mebendazole was given to infected animals for 2 weeks beginning 5 weeks (prepatent) or 16 weeks (patent) after infection. At comparable intervals after drug administration, the animals were reinoculated with infective larvae and the blood eosinophil response was measured over a 5 week period. The response in the animals treated during the prepatent period was higher than the untreated infected controls. Treatment during the patent period had no demonstrable effect. Jirds made artificially microfilaremic by intravenous inoculation of viable filaria before and after the standard infecting dose had a low eosinophil response to infective larvae.
URI: http://hdl.handle.net/10069/21855
ISSN: 00029637
PubMed ID: 2774064
Relational Links: http://www.ajtmh.org/cgi/content/abstract/41/2/183
Rights: Copyright © 1989 by The American Society of Tropical Medicine and Hygiene
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/21855

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