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Lack of Efficacy of High-Dose Intravenous Immunoglobulin Treatment of Severe Thrombocytopenia in Patients with Secondary Dengue Virus Infection


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Title: Lack of Efficacy of High-Dose Intravenous Immunoglobulin Treatment of Severe Thrombocytopenia in Patients with Secondary Dengue Virus Infection
Authors: Dimaano, Efren M. / Saito, Mariko / Honda, Shoko / Miranda, Edna A. / Alonzo, Maria T. G. / Valerio, Myra D. / Mapua, Cynthia A. / Inoue, Shingo / Kumaori, Atsushi / Matias, Ronald / Natividad, Filipinas F. / Oishi, Kazunori
Issue Date: Dec-2007
Publisher: American Society of Tropical Medicine and Hygiene
Citation: American Journal of Tropical Medicine and Hygiene, 77(6), pp.1135-1138; 2007
Abstract: Because most cases of secondary dengue virus infection are associated with an increased level of platelet-associated IgG, a high dose of intravenous immunoglobulin (IVIG) may have an effect on the development of severe thrombocytopenia in this disease. A randomized, controlled study was conducted with two treatment groups consisting of a treatment (IVIG) group (n = 15) and a non-treatment (non-IVIG) group (n = 16) to determine whether a high dose of IVIG is effective in hastening the recovery from thrombocytopenia in patients with secondary dengue virus infection. No significant difference was found in the baseline demographic data between the two groups. No adverse effect of IVIG was observed, but no effect in hastening the recovery of platelet counts was found in patients with secondary dengue infections. The lack of efficacy of IVIG suggests that platelet clearance by macrophages through Fc {gamma} receptors is not a primary mechanism in this disease.
URI: http://hdl.handle.net/10069/21868
ISSN: 00029637
PubMed ID: 18165536
Relational Links: http://www.ajtmh.org/cgi/content/abstract/77/6/1135
Rights: Copyright © 2007 by The American Society of Tropical Medicine and Hygiene
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/21868

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