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Potential of Magnetic Resonance Plaque Imaging Using Superparamagnetic Particles of Iron Oxide for the Detection of Carotid Plaque


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Title: Potential of Magnetic Resonance Plaque Imaging Using Superparamagnetic Particles of Iron Oxide for the Detection of Carotid Plaque
Authors: Kawahara, Ichiro / Nakamoto, Morito / Kitagawa, Naoki / Tsutsumi, Keisuke / Nagata, Izumi / Morikawa, Minoru / Hayashi, Tomayoshi
Issue Date: Apr-2008
Publisher: The Japan Neurosurgical Society
Citation: Neurologia medico-chirurgica, 48(4), pp.157-162; 2008
Abstract: Macrophages and by-products are important in plaque destabilization in atherosclerosis. Ultra-small superparamagnetic particles of iron oxide (SPIO)-enhanced magnetic resonance (MR) imaging may be suitable for the detection of macrophages in atherosclerotic plaques. The present study investigated the potential of MR plaque imaging using SPIO in 10 patients scheduled for carotid endarterectomy before and 24-43 hours after administration of SPIO (fercarbotran, 0.016 ml/kg). Three-dimensional gradient recalled acquisition in the steady state (3D-GRASS) was used for detecting macrophages within plaques. Signal loss on the post-contrast 3D-GRASS images was found in 5 of 10 cases, and accumulation of SPIO particles in the vessel wall was confirmed in 4 of these 5 cases. Intracytoplasmic localization of SPIO particles within recruited macrophages was verified by double staining analysis. A correlation between MR plaque imaging using SPIO and localization of macrophages was demonstrated in 6 of 10 patients. This study indicates that MR plaque imaging using SPIO is a potential functional imaging tool to detect infiltration of macrophages in human atherosclerotic carotid plaque.
Keywords: carotid plaque / functional imaging / high-resolution magnetic resonance imaging / macrophage / superparamagnetic particles of iron oxide
URI: http://hdl.handle.net/10069/21932
ISSN: 04708105
DOI: 10.2176/nmc.48.157
Relational Links: http://ci.nii.ac.jp/naid/110006656285
Rights: Copyright (c) 2008 by The Japan Neurosurgical Society / 本文データは学協会の許諾に基づきCiNiiから複製したものである
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/21932

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