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Gene therapy for gastric diseases.


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Title: Gene therapy for gastric diseases.
Authors: Fumoto, Shintaro / Nishi, Junya / Nakamura, Junzo / Nishida, Koyo
Issue Date: Jun-2008
Publisher: Bentham Science Publishers
Citation: Current Gene Therapy, 8(3), pp.187-200; 2008
Abstract: Gene therapy for gastric cancer and gastric ulcer is a rationalized strategy since various genes correlate with these diseases. Since gene expressions in non-target tissues/cells cause side effects, a selective gene delivery system targeted to the stomach and/or cancer must be developed. The route of vector transfer (direct injection, systemic, intraperitoneal, gastric serosal surface and oral administration) is an important issue which can determine efficacy and safety. Strategies for cancer gene therapy can be categorized as suicide gene therapy, growth inhibition and apoptosis induction, immunotherapy, anti-angiogenesis, and others. Combination of the target gene with other genes and/or strategies such as chemotherapy and virotherapy is promising. Candidates for treatment of gastric ulcer are vascular endothelial growth factor, angiopoietin-1, serum response factor, and cationic host defense peptide cathelicidin. In this review, we discuss stomach- and cancer-targeted gene transfer methods and summarize gene therapy trials for gastric cancer and gastric ulcer.
Keywords: Gastric cancer / carcinoma / gastric ulcer / gene delivery / stomach
URI: http://hdl.handle.net/10069/21982
ISSN: 15665232
DOI: 10.2174/156652308784746431
PubMed ID: 18537593
Rights: (c) 2008 Bentham Science Publishers Ltd.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/21982

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