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Usefulness of intraoperative photodynamic diagnosis using 5-aminolevulinic acid for meningiomas with cranial invasion: technical case report.


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タイトル: Usefulness of intraoperative photodynamic diagnosis using 5-aminolevulinic acid for meningiomas with cranial invasion: technical case report.
その他のタイトル: Photodynamic diagnosis for skull invasion
著者: Morofuji, Yoichi / Matsuo, Takayuki / Hayashi, Yukishige / Suyama, Kazuhiko / Nagata, Izumi
発行日: 2008年 3月
出版者: Lippincott, Williams & Wilkins
引用: Neurosurgery. 62(3) Operative Neurosurgery Supplement 1:102-104, 2008.
抄録: OBJECTIVE: We present a case of a meningioma in which photodynamic diagnosis (PDD) using 5-aminolevulinic acid was very useful in identifying the cranial involvement. CLINICAL PRESENTATION: An 83-year-old woman presented with a bony, hard, immobile bulge in her left forehead. Computed tomographic scans showed a thickening in the left frontal bone with a flat mass underneath. Magnetic resonance imaging scans revealed that enhancing lesions spread to the dura mater and subcutaneous tissue around the thickened frontal bone, reaching the upper margin of the left orbit. INTERVENTION: Intraoperative PDD using 5-aminolevulinic acid indicated the optimal extent of the excision by showing clear fluorescence of affected tissues. The tumor was totally resected and diagnosed as an atypical meningioma. Histopathological examination confirmed the consistency of the extent of tumor invasion with affected lesions on PDD. CONCLUSION: To the best of our knowledge, this is the first case demonstrating the efficacy of PDD using 5-aminolevulinic acid for a meningioma with cranial invasion. Additional studies are warranted, as shown in cases of malignant gliomas.
キーワード: 5-aminolevulinic acid / intraoperative photodynamic diagnosis / meningioma / skull invasion
URI: http://hdl.handle.net/10069/22026
ISSN: 0148396X
DOI: 10.1227/01.neu.0000317378.22820.46
PubMed ID: 18424972
関連リンク : http://journals.lww.com/neurosurgery/Abstract/2008/03001/Usefulness_of_Intraoperative_Photodynamic.12.aspx
権利: Copyright © by the Congress of Neurological Surgeons / This is a non-final version of an article published in final form in "Neurosurgery. 2008 Mar;62(3 Suppl 1):102-104".
資料タイプ: Journal Article
原稿種類: author
出現コレクション:130 学術雑誌論文

引用URI : http://hdl.handle.net/10069/22026

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